{"id":"colpermin","safety":{"commonSideEffects":[{"rate":null,"effect":"Heartburn or reflux"},{"rate":null,"effect":"Allergic reactions (rare)"},{"rate":null,"effect":"Mild gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Peppermint oil contains menthol and other volatile compounds that interact with calcium channels and smooth muscle cells in the intestinal wall, reducing spasm and promoting relaxation. This mechanism helps alleviate symptoms associated with irritable bowel syndrome and other functional gastrointestinal disorders by decreasing abnormal muscle contractions.","oneSentence":"Colpermin is a peppermint oil-based formulation that acts as an antispasmodic agent to reduce smooth muscle contractions in the gastrointestinal tract.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:43.116Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Irritable bowel syndrome (IBS) with abdominal pain and cramping"},{"name":"Functional gastrointestinal disorders"}]},"trialDetails":[{"nctId":"NCT02364830","phase":"PHASE3","title":"Clinical Effectiveness of Enteric Coated(E.C.) Anise-oil on Irritable Bowel Syndrome","status":"COMPLETED","sponsor":"Shiraz University of Medical Sciences","startDate":"2013-04","conditions":"Irritable Bowel Syndrome","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Group C"],"phase":"phase_3","status":"active","brandName":"Colpermin®","genericName":"Colpermin®","companyName":"Shiraz University of Medical Sciences","companyId":"shiraz-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colpermin is a peppermint oil-based formulation that acts as an antispasmodic agent to reduce smooth muscle contractions in the gastrointestinal tract. Used for Irritable bowel syndrome (IBS) with abdominal pain and cramping, Functional gastrointestinal disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}