Last reviewed · How we verify
Colonic lavage with polyethylene glycol
Polyethylene glycol (PEG) solution acts as an osmotic laxative that draws water into the colon to soften stool and promote bowel evacuation.
Polyethylene glycol (PEG) solution acts as an osmotic laxative that draws water into the colon to soften stool and promote bowel evacuation. Used for Bowel preparation prior to colonoscopy, Bowel preparation prior to colorectal surgery, Bowel cleansing for diagnostic imaging procedures.
At a glance
| Generic name | Colonic lavage with polyethylene glycol |
|---|---|
| Also known as | PEG |
| Sponsor | Changi General Hospital |
| Drug class | Osmotic laxative |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology |
| Phase | FDA-approved |
Mechanism of action
PEG is a non-absorbable polymer that creates an osmotic gradient in the intestinal lumen, retaining water and electrolytes within the bowel. This increases stool bulk and fluidity, facilitating complete colonic cleansing. Colonic lavage with PEG is used to prepare the colon for diagnostic or therapeutic procedures by removing fecal matter and debris.
Approved indications
- Bowel preparation prior to colonoscopy
- Bowel preparation prior to colorectal surgery
- Bowel cleansing for diagnostic imaging procedures
Common side effects
- Nausea
- Vomiting
- Abdominal bloating
- Abdominal cramping
- Anal irritation
Key clinical trials
- Effect of Probiotic on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers (PHASE4)
- Stability of the Microbiome in IBD and IBS (NA)
- Loop Ileostomy With Colonic Lavage for Fulminant Clostridium Difficile Colitis (NA)
- PillCam® Platform With the PillCam Crohn's Disease Capsule (PHASE1, PHASE2)
- Colonic Irrigation for Colonoscopy Preparation (NA)
- Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage (PHASE4)
- Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy (NA)
- Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: