{"id":"colonic-lavage-with-polyethylene-glycol","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea"},{"rate":"5-15","effect":"Vomiting"},{"rate":"20-40","effect":"Abdominal bloating"},{"rate":"15-30","effect":"Abdominal cramping"},{"rate":"5-10","effect":"Anal irritation"}]},"_chembl":{"chemblId":"CHEMBL1201478","moleculeType":"Small molecule"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PEG is a non-absorbable polymer that creates an osmotic gradient in the intestinal lumen, retaining water and electrolytes within the bowel. This increases stool bulk and fluidity, facilitating complete colonic cleansing. Colonic lavage with PEG is used to prepare the colon for diagnostic or therapeutic procedures by removing fecal matter and debris.","oneSentence":"Polyethylene glycol (PEG) solution acts as an osmotic laxative that draws water into the colon to soften stool and promote bowel evacuation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:30.378Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel preparation prior to colonoscopy"},{"name":"Bowel preparation prior to colorectal surgery"},{"name":"Bowel cleansing for diagnostic imaging procedures"}]},"trialDetails":[{"nctId":"NCT05083572","phase":"PHASE4","title":"Effect of Probiotic on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers","status":"UNKNOWN","sponsor":"Changi General Hospital","startDate":"2021-03-10","conditions":"Dysbiosis","enrollment":32},{"nctId":"NCT03395548","phase":"NA","title":"Stability of the Microbiome in IBD and IBS","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2017-08-25","conditions":"Microbiota","enrollment":50},{"nctId":"NCT02347280","phase":"NA","title":"Loop Ileostomy With Colonic Lavage for Fulminant Clostridium Difficile Colitis","status":"TERMINATED","sponsor":"Jewish General Hospital","startDate":"2015-01","conditions":"Fulminant Clostridium Difficile Colitis","enrollment":12},{"nctId":"NCT01631435","phase":"PHASE1, PHASE2","title":"PillCam® Platform With the PillCam Crohn's Disease Capsule","status":"COMPLETED","sponsor":"Medtronic - MITG","startDate":"2012-06","conditions":"Crohn's Disease","enrollment":75},{"nctId":"NCT02647229","phase":"NA","title":"Colonic Irrigation for Colonoscopy Preparation","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2014-10","conditions":"Colonoscopy","enrollment":""},{"nctId":"NCT00745095","phase":"PHASE4","title":"Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage","status":"COMPLETED","sponsor":"US Department of Veterans Affairs","startDate":"2009-03","conditions":"Spinal Cord Injury","enrollment":360},{"nctId":"NCT01610856","phase":"NA","title":"Single Dose Versus Split Dose Polyethylene Glycol-based Colonic Lavage for Colonoscopy","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2010-03","conditions":"Colonoscopy Preparation","enrollment":250},{"nctId":"NCT00427089","phase":"PHASE3","title":"Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening","status":"COMPLETED","sponsor":"Norgine","startDate":"2004-09","conditions":"Colonoscopy","enrollment":360}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["PEG"],"phase":"marketed","status":"active","brandName":"Colonic lavage with polyethylene glycol","genericName":"Colonic lavage with polyethylene glycol","companyName":"Changi General Hospital","companyId":"changi-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Polyethylene glycol (PEG) solution acts as an osmotic laxative that draws water into the colon to soften stool and promote bowel evacuation. Used for Bowel preparation prior to colonoscopy, Bowel preparation prior to colorectal surgery, Bowel cleansing for diagnostic imaging procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}