Last reviewed · How we verify
Codeine Phosphate Analgesia
Codeine phosphate is an opioid analgesic that binds to opioid receptors in the central nervous system to reduce pain perception.
Codeine phosphate is an opioid analgesic that binds to opioid receptors in the central nervous system to reduce pain perception. Used for Mild to moderate pain in pediatric and adult patients, Cough suppression.
At a glance
| Generic name | Codeine Phosphate Analgesia |
|---|---|
| Sponsor | Institute of Child Health |
| Drug class | Opioid analgesic |
| Target | Mu (μ) opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Codeine is a weak opioid agonist that acts primarily on mu (μ) opioid receptors in the brain and spinal cord. It also undergoes hepatic metabolism to morphine, which contributes significantly to its analgesic effects. The drug modulates pain signaling pathways and is commonly used for mild to moderate pain management.
Approved indications
- Mild to moderate pain in pediatric and adult patients
- Cough suppression
Common side effects
- Constipation
- Drowsiness
- Nausea
- Dizziness
- Respiratory depression
- Dependence potential
Key clinical trials
- An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery (NA)
- Naproxen Codeine in Arthroscopic Surgery (PHASE4)
- Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain (PHASE4)
- Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |