{"id":"codeine-phosphate-analgesia","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"25-30","effect":"Drowsiness"},{"rate":"15-25","effect":"Nausea"},{"rate":"10-20","effect":"Dizziness"},{"rate":"null","effect":"Respiratory depression"},{"rate":"null","effect":"Dependence potential"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Codeine is a weak opioid agonist that acts primarily on mu (μ) opioid receptors in the brain and spinal cord. It also undergoes hepatic metabolism to morphine, which contributes significantly to its analgesic effects. The drug modulates pain signaling pathways and is commonly used for mild to moderate pain management.","oneSentence":"Codeine phosphate is an opioid analgesic that binds to opioid receptors in the central nervous system to reduce pain perception.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:19:23.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain in pediatric and adult patients"},{"name":"Cough suppression"}]},"trialDetails":[{"nctId":"NCT04874675","phase":"NA","title":"An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery","status":"SUSPENDED","sponsor":"University of Zimbabwe","startDate":"2023-03","conditions":"Impacted Third Molar Tooth, PAIN","enrollment":78},{"nctId":"NCT01952652","phase":"PHASE4","title":"Naproxen Codeine in Arthroscopic Surgery","status":"COMPLETED","sponsor":"Baskent University","startDate":"2013-01","conditions":"Arthroscopic Meniscus Surgery","enrollment":61},{"nctId":"NCT00378937","phase":"PHASE4","title":"Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain","status":"COMPLETED","sponsor":"University Hospitals Bristol and Weston NHS Foundation Trust","startDate":"2004-01","conditions":"Pain, Unspecified Adult Solid Tumor, Protocol Specific","enrollment":30},{"nctId":"NCT00386269","phase":"PHASE4","title":"Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants","status":"COMPLETED","sponsor":"Institute of Child Health","startDate":"2004-01","conditions":"Cleft Palate Repair","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1291,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Codeine Phosphate Analgesia","genericName":"Codeine Phosphate Analgesia","companyName":"Institute of Child Health","companyId":"institute-of-child-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Codeine phosphate is an opioid analgesic that binds to opioid receptors in the central nervous system to reduce pain perception. Used for Mild to moderate pain in pediatric and adult patients, Cough suppression.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}