What is Cociane hydrochloride 4% used for?

Cociane hydrochloride 4% is indicated for Topical anesthesia and hemostasis in nasal and otolaryngologic surgery.

Who makes Cociane hydrochloride 4%?

Cociane hydrochloride 4% is developed by Rigshospitalet, Denmark.

What development phase is Cociane hydrochloride 4% in?

Cociane hydrochloride 4% is in Phase 3.

What are the side effects of Cociane hydrochloride 4%?

Common side effects include Tachycardia, Hypertension, Tremor, Anxiety, Headache, Cardiac arrhythmias.

Last reviewed 2026-04-22 · How we verify

Cociane hydrochloride 4%

Rigshospitalet, Denmark · Phase 3 active Small molecule

Cocaine hydrochloride is a local anesthetic and vasoconstrictor that blocks the reuptake of norepinephrine, dopamine, and serotonin at nerve terminals, producing topical anesthesia and hemostasis.

Cocaine hydrochloride is a local anesthetic and vasoconstrictor that blocks the reuptake of norepinephrine, dopamine, and serotonin at nerve terminals, producing topical anesthesia and hemostasis. Used for Topical anesthesia and hemostasis in nasal and otolaryngologic surgery.

At a glance

Generic name	Cociane hydrochloride 4%
Sponsor	Rigshospitalet, Denmark
Drug class	Local anesthetic with vasoconstrictive properties
Target	Monoamine reuptake transporters (norepinephrine, dopamine, serotonin)
Modality	Small molecule
Therapeutic area	Surgery/Anesthesia
Phase	Phase 3

Mechanism of action

Cocaine hydrochloride works by inhibiting the reuptake of monoamine neurotransmitters at nerve endings, which increases their concentration in the synaptic cleft and produces local anesthetic effects. Additionally, it causes vasoconstriction by enhancing noradrenergic activity, which reduces bleeding and improves surgical visibility. The 4% formulation is typically used for topical application in nasal and otolaryngologic procedures.

Approved indications

Topical anesthesia and hemostasis in nasal and otolaryngologic surgery

Common side effects

Tachycardia
Hypertension
Tremor
Anxiety
Headache
Cardiac arrhythmias

Key clinical trials

Cocaine, Lidocaine/xylometazoline and Saline for Nasal Analgesia (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

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