{"id":"cociane-hydrochloride-4","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Cardiac arrhythmias"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cocaine hydrochloride works by inhibiting the reuptake of monoamine neurotransmitters at nerve endings, which increases their concentration in the synaptic cleft and produces local anesthetic effects. Additionally, it causes vasoconstriction by enhancing noradrenergic activity, which reduces bleeding and improves surgical visibility. The 4% formulation is typically used for topical application in nasal and otolaryngologic procedures.","oneSentence":"Cocaine hydrochloride is a local anesthetic and vasoconstrictor that blocks the reuptake of norepinephrine, dopamine, and serotonin at nerve terminals, producing topical anesthesia and hemostasis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:34.100Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia and hemostasis in nasal and otolaryngologic surgery"}]},"trialDetails":[{"nctId":"NCT06443255","phase":"PHASE3","title":"Cocaine, Lidocaine/xylometazoline and Saline for Nasal Analgesia","status":"COMPLETED","sponsor":"Rigshospitalet, Denmark","startDate":"2024-07-01","conditions":"Analgesia","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cociane hydrochloride 4%","genericName":"Cociane hydrochloride 4%","companyName":"Rigshospitalet, Denmark","companyId":"rigshospitalet-denmark","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cocaine hydrochloride is a local anesthetic and vasoconstrictor that blocks the reuptake of norepinephrine, dopamine, and serotonin at nerve terminals, producing topical anesthesia and hemostasis. Used for Topical anesthesia and hemostasis in nasal and otolaryngologic surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}