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Clopidogrel reloading
Clopidogrel reloading involves administering a higher initial dose of clopidogrel to rapidly achieve platelet inhibition in acute coronary syndromes or percutaneous coronary intervention.
Clopidogrel reloading involves administering a higher initial dose of clopidogrel to rapidly achieve platelet inhibition in acute coronary syndromes or percutaneous coronary intervention. Used for Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction), Percutaneous coronary intervention with stent placement, Secondary prevention of atherothrombotic events.
At a glance
| Generic name | Clopidogrel reloading |
|---|---|
| Also known as | Clopidogrel = KARDOGREL |
| Sponsor | University of Pecs |
| Drug class | P2Y12 receptor antagonist / Thienopyridine antiplatelet agent |
| Target | P2Y12 receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits the P2Y12 adenosine diphosphate receptor on platelets, preventing platelet aggregation. A loading dose (typically 600 mg) is used to rapidly achieve therapeutic platelet inhibition levels, which is faster than maintenance dosing alone. This approach is particularly important in acute coronary syndromes and during percutaneous coronary intervention to reduce thrombotic events.
Approved indications
- Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)
- Percutaneous coronary intervention with stent placement
- Secondary prevention of atherothrombotic events
Common side effects
- Bleeding
- Thrombotic thrombocytopenic purpura (TTP)
- Neutropenia
- Gastrointestinal hemorrhage
Key clinical trials
- The Effect of Reloading Prasugrel in a Patient Who Has Already Received a Loading Dose (LD) of Clopidogrel (PHASE4)
- Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients (NA)
- Ticagrelor Loading Dose Versus Clopidogrel Loading and Reloading With Ticagrelor. (PHASE3)
- Reloading Prasugrel or Clopidogrel on High Platelet Reactivity Before Percutaneous Coronary Intervention (PHASE3)
- Prasugrel Versus Clopidogrel to TREAT High Platelet Reactivity (PHASE4)
- Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting (PHASE4)
- Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy (PHASE4)
- Clopidogrel Reloading in Clopidogrel Resistant Patients With ACS (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |