{"id":"clopidogrel-reloading","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Thrombotic thrombocytopenic purpura (TTP)"},{"rate":null,"effect":"Neutropenia"},{"rate":null,"effect":"Gastrointestinal hemorrhage"}]},"_chembl":{"chemblId":"CHEMBL1771","moleculeType":"Small molecule","molecularWeight":"321.83"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clopidogrel is a thienopyridine antiplatelet agent that irreversibly inhibits the P2Y12 adenosine diphosphate receptor on platelets, preventing platelet aggregation. A loading dose (typically 600 mg) is used to rapidly achieve therapeutic platelet inhibition levels, which is faster than maintenance dosing alone. This approach is particularly important in acute coronary syndromes and during percutaneous coronary intervention to reduce thrombotic events.","oneSentence":"Clopidogrel reloading involves administering a higher initial dose of clopidogrel to rapidly achieve platelet inhibition in acute coronary syndromes or percutaneous coronary intervention.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:14.686Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)"},{"name":"Percutaneous coronary intervention with stent placement"},{"name":"Secondary prevention of atherothrombotic events"}]},"trialDetails":[{"nctId":"NCT01365221","phase":"PHASE4","title":"The Effect of Reloading Prasugrel in a Patient Who Has Already Received a Loading Dose (LD) of Clopidogrel","status":"COMPLETED","sponsor":"Medstar Health Research Institute","startDate":"2010-10","conditions":"Acute Coronary Syndrome","enrollment":77},{"nctId":"NCT03759067","phase":"NA","title":"Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients","status":"COMPLETED","sponsor":"Korea University Anam Hospital","startDate":"2010-10-18","conditions":"Angina, Stable","enrollment":511},{"nctId":"NCT01961856","phase":"PHASE3","title":"Ticagrelor Loading Dose Versus Clopidogrel Loading and Reloading With Ticagrelor.","status":"COMPLETED","sponsor":"University of Patras","startDate":"2013-09","conditions":"Platelet Reactivity","enrollment":74},{"nctId":"NCT01609647","phase":"PHASE3","title":"Reloading Prasugrel or Clopidogrel on High Platelet Reactivity Before Percutaneous Coronary Intervention","status":"COMPLETED","sponsor":"Dong-A University","startDate":"2012-09","conditions":"Acute Coronary Syndrome","enrollment":76},{"nctId":"NCT01493999","phase":"PHASE4","title":"Prasugrel Versus Clopidogrel to TREAT High Platelet Reactivity","status":"COMPLETED","sponsor":"University of Pecs","startDate":"2011-09","conditions":"Acute Coronary Syndrome","enrollment":147},{"nctId":"NCT01572623","phase":"PHASE4","title":"Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting","status":"UNKNOWN","sponsor":"Campus Bio-Medico University","startDate":"2011-07","conditions":"Carotid Stenosis","enrollment":150},{"nctId":"NCT01572129","phase":"PHASE4","title":"Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy","status":"UNKNOWN","sponsor":"Campus Bio-Medico University","startDate":"2011-11","conditions":"Acute Coronary Syndrome, Myocardial Infarction","enrollment":240},{"nctId":"NCT00444132","phase":"PHASE3","title":"Clopidogrel Reloading in Clopidogrel Resistant Patients With ACS","status":"COMPLETED","sponsor":"Sheba Medical Center","startDate":"2005-03","conditions":"Clopidogrel Non-Responsiveness","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clopidogrel = KARDOGREL"],"phase":"marketed","status":"active","brandName":"Clopidogrel reloading","genericName":"Clopidogrel reloading","companyName":"University of Pecs","companyId":"university-of-pecs","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clopidogrel reloading involves administering a higher initial dose of clopidogrel to rapidly achieve platelet inhibition in acute coronary syndromes or percutaneous coronary intervention. Used for Acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction), Percutaneous coronary intervention with stent placement, Secondary prevention of atherothrombotic events.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}