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clomiphene citrate treatment
clomiphene citrate treatment is a Selective estrogen receptor modulator (SERM) Small molecule drug developed by Sheba Medical Center. It is currently in Phase 3 development for Anovulation and infertility in women, Male infertility / hypogonadism.
Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion to stimulate ovulation or spermatogenesis.
Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion to stimulate ovulation or spermatogenesis. Used for Anovulation and infertility in women, Male infertility / hypogonadism.
At a glance
| Generic name | clomiphene citrate treatment |
|---|---|
| Sponsor | Sheba Medical Center |
| Drug class | Selective estrogen receptor modulator (SERM) |
| Target | Estrogen receptor (ER-α and ER-β) |
| Modality | Small molecule |
| Therapeutic area | Reproductive Endocrinology / Fertility |
| Phase | Phase 3 |
Mechanism of action
Clomiphene acts as a competitive antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback that estrogen exerts on GnRH and gonadotropin release. This disinhibition leads to increased FSH and LH secretion, which stimulates follicle development in women and testosterone production in men. The net effect is restoration or enhancement of reproductive hormone signaling.
Approved indications
- Anovulation and infertility in women
- Male infertility / hypogonadism
Common side effects
- Hot flashes
- Ovarian hyperstimulation syndrome (OHSS)
- Abdominal discomfort / bloating
- Nausea
- Visual disturbances
- Headache
Key clinical trials
- FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (PHASE3)
- INTEnsity of ovariaN Stimulation and Embryo Quality (PHASE4)
- The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.
- The Effect of Therapy Combination in PCOS With Dlbs 3233 (EARLY_PHASE1)
- Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (NA)
- Interest of Clomiphene Citrate in Patients With Non-obstructive Azoospermia on the Quantity of Sperm Cells (PHASE3)
- Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation (PHASE4)
- Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg® (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- clomiphene citrate treatment CI brief — competitive landscape report
- clomiphene citrate treatment updates RSS · CI watch RSS
- Sheba Medical Center portfolio CI
Frequently asked questions about clomiphene citrate treatment
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Related
- Drug class: All Selective estrogen receptor modulator (SERM) drugs
- Target: All drugs targeting Estrogen receptor (ER-α and ER-β)
- Manufacturer: Sheba Medical Center — full pipeline
- Therapeutic area: All drugs in Reproductive Endocrinology / Fertility
- Indication: Drugs for Anovulation and infertility in women
- Indication: Drugs for Male infertility / hypogonadism
- Compare: clomiphene citrate treatment vs similar drugs
- Pricing: clomiphene citrate treatment cost, discount & access