{"id":"clomiphene-citrate-treatment","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Hot flashes"},{"rate":"1-2","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5-10","effect":"Abdominal discomfort / bloating"},{"rate":"5-10","effect":"Nausea"},{"rate":"1-2","effect":"Visual disturbances"},{"rate":"5","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Clomiphene acts as a competitive antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback that estrogen exerts on GnRH and gonadotropin release. This disinhibition leads to increased FSH and LH secretion, which stimulates follicle development in women and testosterone production in men. The net effect is restoration or enhancement of reproductive hormone signaling.","oneSentence":"Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion to stimulate ovulation or spermatogenesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:06:24.123Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anovulation and infertility in women"},{"name":"Male infertility / hypogonadism"}]},"trialDetails":[{"nctId":"NCT05364008","phase":"PHASE3","title":"FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea","status":"ACTIVE_NOT_RECRUITING","sponsor":"Yale University","startDate":"2023-01-05","conditions":"Leiomyoma, Uterine","enrollment":33},{"nctId":"NCT04983173","phase":"PHASE4","title":"INTEnsity of ovariaN Stimulation and Embryo 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