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Clobetasol 0.05% Emollient Top Cream
Clobetasol 0.05% Emollient Top Cream is a Topical corticosteroid (Class I, super-potent) Small molecule drug developed by Ruhr University of Bochum. It is currently in Phase 3 development for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema). Also known as: Dermoxin (Germany), Temovate, Clobex, Dermovate, Impoyz.
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema).
At a glance
| Generic name | Clobetasol 0.05% Emollient Top Cream |
|---|---|
| Also known as | Dermoxin (Germany), Temovate, Clobex, Dermovate, Impoyz |
| Sponsor | Ruhr University of Bochum |
| Drug class | Topical corticosteroid (Class I, super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory responses. The emollient cream formulation enhances skin penetration and provides additional moisturizing benefits to affected skin.
Approved indications
- Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Local skin irritation
- Systemic corticosteroid absorption (with prolonged use or occlusion)
Key clinical trials
- Laser vs Clobetasol for Lichen Sclerosus (PHASE3)
- A Clinical Trial to Compare Topical Agents in Adults With Mild to Moderate Atopic Dermatitis (AD) (PHASE1)
- Comparison Between Corticosteroid and Topical Steroids in the DRESS (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clobetasol 0.05% Emollient Top Cream CI brief — competitive landscape report
- Clobetasol 0.05% Emollient Top Cream updates RSS · CI watch RSS
- Ruhr University of Bochum portfolio CI
Frequently asked questions about Clobetasol 0.05% Emollient Top Cream
What is Clobetasol 0.05% Emollient Top Cream?
How does Clobetasol 0.05% Emollient Top Cream work?
What is Clobetasol 0.05% Emollient Top Cream used for?
Who makes Clobetasol 0.05% Emollient Top Cream?
Is Clobetasol 0.05% Emollient Top Cream also known as anything else?
What drug class is Clobetasol 0.05% Emollient Top Cream in?
What development phase is Clobetasol 0.05% Emollient Top Cream in?
What are the side effects of Clobetasol 0.05% Emollient Top Cream?
What does Clobetasol 0.05% Emollient Top Cream target?
Related
- Drug class: All Topical corticosteroid (Class I, super-potent) drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: Ruhr University of Bochum — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)
- Also known as: Dermoxin (Germany), Temovate, Clobex, Dermovate, Impoyz
- Compare: Clobetasol 0.05% Emollient Top Cream vs similar drugs
- Pricing: Clobetasol 0.05% Emollient Top Cream cost, discount & access