{"id":"clobetasol-0-05-emollient-top-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Systemic corticosteroid absorption (with prolonged use or occlusion)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clobetasol propionate is a Class I (super-potent) corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory responses. The emollient cream formulation enhances skin penetration and provides additional moisturizing benefits to affected skin.","oneSentence":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:06:22.262Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)"}]},"trialDetails":[{"nctId":"NCT05010421","phase":"PHASE3","title":"Laser vs Clobetasol for Lichen Sclerosus","status":"COMPLETED","sponsor":"Ruhr University of Bochum","startDate":"2021-11-02","conditions":"Lichen Sclerosus","enrollment":246},{"nctId":"NCT02376049","phase":"PHASE1","title":"A Clinical Trial to Compare Topical Agents in Adults With Mild to Moderate Atopic Dermatitis (AD)","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-02","conditions":"Atopic Dermatitis","enrollment":30},{"nctId":"NCT01987076","phase":"NA","title":"Comparison Between Corticosteroid and Topical Steroids in the DRESS","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-10","conditions":"Drug Rash With Eosinophilia and Systemic Symptoms","enrollment":112}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dermoxin (Germany), Temovate, Clobex, Dermovate, Impoyz"],"phase":"phase_3","status":"active","brandName":"Clobetasol 0.05% Emollient Top Cream","genericName":"Clobetasol 0.05% Emollient Top Cream","companyName":"Ruhr University of Bochum","companyId":"ruhr-university-of-bochum","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}