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cisplatin and fluorouracil
cisplatin and fluorouracil is a Chemotherapy combination (platinum agent + antimetabolite) Small molecule drug developed by Sun Yat-sen University. It is currently in Phase 3 development for Advanced or metastatic cancers (specific indication under investigation in phase 3 trial not specified). Also known as: cisplatin and fluorouracil (PF).
Cisplatin and fluorouracil work together as a chemotherapy combination to damage cancer cell DNA and inhibit nucleotide synthesis, preventing tumor growth and proliferation.
Cisplatin and fluorouracil work together as a chemotherapy combination to damage cancer cell DNA and inhibit nucleotide synthesis, preventing tumor growth and proliferation. Used for Advanced or metastatic cancers (specific indication under investigation in phase 3 trial not specified).
At a glance
| Generic name | cisplatin and fluorouracil |
|---|---|
| Also known as | cisplatin and fluorouracil (PF) |
| Sponsor | Sun Yat-sen University |
| Drug class | Chemotherapy combination (platinum agent + antimetabolite) |
| Target | DNA (cisplatin); thymidylate synthase and nucleotide metabolism (fluorouracil) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Cisplatin is a platinum-based alkylating agent that forms DNA cross-links, causing irreversible damage to cancer cells. Fluorouracil (5-FU) is an antimetabolite that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis. Together, they provide synergistic cytotoxic effects against rapidly dividing cancer cells.
Approved indications
- Advanced or metastatic cancers (specific indication under investigation in phase 3 trial not specified)
Common side effects
- Nausea and vomiting
- Myelosuppression (neutropenia, thrombocytopenia)
- Nephrotoxicity
- Ototoxicity
- Peripheral neuropathy
- Mucositis
- Diarrhea
- Alopecia
Key clinical trials
- Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer (PHASE3)
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies (PHASE1)
- Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial (PHASE2)
- Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer (PHASE3)
- Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors (PHASE2)
- A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (PHASE3)
- Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU for Locally Advanced Head and Neck Squamous Cell Carcinoma (PHASE1)
- A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- cisplatin and fluorouracil CI brief — competitive landscape report
- cisplatin and fluorouracil updates RSS · CI watch RSS
- Sun Yat-sen University portfolio CI
Frequently asked questions about cisplatin and fluorouracil
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Related
- Drug class: All Chemotherapy combination (platinum agent + antimetabolite) drugs
- Target: All drugs targeting DNA (cisplatin); thymidylate synthase and nucleotide metabolism (fluorouracil)
- Manufacturer: Sun Yat-sen University — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Advanced or metastatic cancers (specific indication under investigation in phase 3 trial not specified)
- Also known as: cisplatin and fluorouracil (PF)
- Compare: cisplatin and fluorouracil vs similar drugs
- Pricing: cisplatin and fluorouracil cost, discount & access