Last reviewed · How we verify
Cimifuga Racemosa
Cimicifuga racemosa (black cohosh) is a herbal extract that modulates estrogen-like activity and may reduce vasomotor symptoms through serotonergic and other neuroendocrine pathways.
Cimicifuga racemosa (black cohosh) is a herbal extract that modulates estrogen-like activity and may reduce vasomotor symptoms through serotonergic and other neuroendocrine pathways. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Menopausal mood and sleep disturbances.
At a glance
| Generic name | Cimifuga Racemosa |
|---|---|
| Also known as | Clifemin, Acteia |
| Sponsor | Federal University of Minas Gerais |
| Drug class | Herbal extract / phytoestrogen |
| Modality | Small molecule |
| Therapeutic area | Women's Health / Menopause |
| Phase | FDA-approved |
Mechanism of action
The rhizome of Cimicifuga racemosa contains phytoestrogens and other bioactive compounds that interact with estrogen receptors and serotonin pathways. It is traditionally used to alleviate menopausal symptoms such as hot flashes and night sweats, though the exact molecular mechanisms remain incompletely characterized. The extract may also have anti-inflammatory and antioxidant properties.
Approved indications
- Menopausal vasomotor symptoms (hot flashes, night sweats)
- Menopausal mood and sleep disturbances
Common side effects
- Gastrointestinal upset
- Headache
- Dizziness
- Rash
Key clinical trials
- Vascular Effect of CIMICIFUGA RACEMOSA (NA)
- Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cimifuga Racemosa CI brief — competitive landscape report
- Cimifuga Racemosa updates RSS · CI watch RSS
- Federal University of Minas Gerais portfolio CI