{"id":"cimifuga-racemosa","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":{"setId":"8529e7f1-0c8e-ab5d-e053-2991aa0ab412","title":"CIMIFUGA RACEMOSA (BLACK COHOSH\t) PELLET [BOIRON]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The rhizome of Cimicifuga racemosa contains phytoestrogens and other bioactive compounds that interact with estrogen receptors and serotonin pathways. It is traditionally used to alleviate menopausal symptoms such as hot flashes and night sweats, though the exact molecular mechanisms remain incompletely characterized. The extract may also have anti-inflammatory and antioxidant properties.","oneSentence":"Cimicifuga racemosa (black cohosh) is a herbal extract that modulates estrogen-like activity and may reduce vasomotor symptoms through serotonergic and other neuroendocrine pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T06:00:21.895Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"},{"name":"Menopausal mood and sleep disturbances"}]},"trialDetails":[{"nctId":"NCT03786809","phase":"NA","title":"Vascular Effect of CIMICIFUGA RACEMOSA","status":"COMPLETED","sponsor":"Federal University of Minas Gerais","startDate":"2016-06","conditions":"Postmenopausal Symptoms","enrollment":60},{"nctId":"NCT02352597","phase":"PHASE4","title":"Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS","status":"COMPLETED","sponsor":"Cairo University","startDate":"2013-01","conditions":"Polycystic Ovaries","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Clifemin","Acteia"],"phase":"marketed","status":"active","brandName":"Cimifuga Racemosa","genericName":"Cimifuga Racemosa","companyName":"Federal University of Minas Gerais","companyId":"federal-university-of-minas-gerais","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cimicifuga racemosa (black cohosh) is a herbal extract that modulates estrogen-like activity and may reduce vasomotor symptoms through serotonergic and other neuroendocrine pathways. Used for Menopausal vasomotor symptoms (hot flashes, night sweats), Menopausal mood and sleep disturbances.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}