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Cholecalciferol 100 000 UI
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency, Hypocalcemia, Osteomalacia.
At a glance
| Generic name | Cholecalciferol 100 000 UI |
|---|---|
| Also known as | Uvedose |
| Sponsor | University Hospital, Tours |
| Drug class | Vitamin D supplement |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Bone Health / Immunology |
| Phase | FDA-approved |
Mechanism of action
Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). The active metabolite binds to vitamin D receptors in the intestine, bone, and kidney to increase calcium absorption, maintain serum calcium and phosphate levels, and support bone mineralization. Additionally, vitamin D receptors are present on immune cells, where calcitriol modulates T-cell and B-cell function and inflammatory responses.
Approved indications
- Vitamin D deficiency
- Hypocalcemia
- Osteomalacia
- Rickets
- Hypoparathyroidism
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Vomiting
- Constipation
- Headache
Key clinical trials
- VITamine D Supplementation in RenAL Transplant Recipients - VITALE (PHASE4)
- Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. (PHASE4)
- Myocardial Function and Vitamin D Supplementation in Diabetes. (NA)
- The Effect of Supplementation of Vitamin D3 on Inflammation Induced by 100 km Running, Iron Metabolism and Erythropoiesis (NA)
- Assessing the Impact of a Mode of Vitamin D Supplementation (Sequential Dose vs Daily Dose) on the Incidence of Hypercalciuria in Subjets Aged From 2 to 18 Years (NA)
- Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint (PHASE3)
- Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking (PHASE4)
- Vitamin D Supplementation in Systemic Lupus Erythematosus
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cholecalciferol 100 000 UI CI brief — competitive landscape report
- Cholecalciferol 100 000 UI updates RSS · CI watch RSS
- University Hospital, Tours portfolio CI