{"id":"cholecalciferol-100-000-ui","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1042","moleculeType":"Small molecule","molecularWeight":"384.65"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). The active metabolite binds to vitamin D receptors in the intestine, bone, and kidney to increase calcium absorption, maintain serum calcium and phosphate levels, and support bone mineralization. Additionally, vitamin D receptors are present on immune cells, where calcitriol modulates T-cell and B-cell function and inflammatory responses.","oneSentence":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:24.261Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency"},{"name":"Hypocalcemia"},{"name":"Osteomalacia"},{"name":"Rickets"},{"name":"Hypoparathyroidism"}]},"trialDetails":[{"nctId":"NCT01431430","phase":"PHASE4","title":"VITamine D Supplementation in RenAL Transplant Recipients - VITALE","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2012-01-06","conditions":"Renal Transplant Candidate for Right Kidney","enrollment":538},{"nctId":"NCT02238418","phase":"PHASE4","title":"Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria.","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2014-09","conditions":"Chronic Kidney Disease, Renal Transplantation, Nephrotic Syndrome","enrollment":43},{"nctId":"NCT03437421","phase":"NA","title":"Myocardial Function and Vitamin D Supplementation in Diabetes.","status":"COMPLETED","sponsor":"University of Avignon","startDate":"2018-02-04","conditions":"Diabetes Complications, Vitamin D Deficiency, Vitamin D Supplementation","enrollment":100},{"nctId":"NCT05880030","phase":"NA","title":"The Effect of Supplementation of Vitamin D3 on Inflammation Induced by 100 km Running, Iron Metabolism and Erythropoiesis","status":"COMPLETED","sponsor":"Gdansk University of Physical Education and Sport","startDate":"2016-10-19","conditions":"Inflammation; Muscle, Iron Metabolism, Ineffective Erythropoiesis","enrollment":40},{"nctId":"NCT02975492","phase":"NA","title":"Assessing the Impact of a Mode of Vitamin D Supplementation (Sequential Dose vs Daily Dose) on the Incidence of Hypercalciuria in Subjets Aged From 2 to 18 Years","status":"UNKNOWN","sponsor":"University Hospital, Montpellier","startDate":"2017-12-14","conditions":"Transient Hypercalciuria","enrollment":280},{"nctId":"NCT02185222","phase":"PHASE3","title":"Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2014-10-23","conditions":"Memory Disorders, Age-Related Cognitive Decline","enrollment":68},{"nctId":"NCT03615833","phase":"PHASE4","title":"Pilot Study of Vitamin D Screening Use in Peripheral Arterial Disease Patient Over Maximum Distance Walking","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2019-03-11","conditions":"Peripheral Arterial Disease","enrollment":27},{"nctId":"NCT01413230","phase":"","title":"Vitamin D Supplementation in Systemic Lupus Erythematosus","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-01","conditions":"Vitamin D Deficiency","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Uvedose"],"phase":"marketed","status":"active","brandName":"Cholecalciferol 100 000 UI","genericName":"Cholecalciferol 100 000 UI","companyName":"University Hospital, Tours","companyId":"university-hospital-tours","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency, Hypocalcemia, Osteomalacia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}