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Chloroprocaine Injection
Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia, Peripheral nerve blocks, Dental anesthesia.
At a glance
| Generic name | Chloroprocaine Injection |
|---|---|
| Sponsor | Nova Scotia Health Authority |
| Drug class | Local anesthetic (ester) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Chloroprocaine is an ester-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the generation and propagation of action potentials in sensory, motor, and autonomic nerves. It has a rapid onset and short duration of action, making it suitable for infiltration anesthesia and nerve blocks.
Approved indications
- Local infiltration anesthesia
- Peripheral nerve blocks
- Dental anesthesia
Common side effects
- Transient paresthesia
- Allergic reactions (rare with ester metabolites)
- Systemic toxicity (with overdose)
- Local tissue irritation
Key clinical trials
- The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population (PHASE2)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches (PHASE4)
- Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty (PHASE4)
- Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (PHASE4)
- Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section (NA)
- Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery (PHASE4)
- Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chloroprocaine Injection CI brief — competitive landscape report
- Chloroprocaine Injection updates RSS · CI watch RSS
- Nova Scotia Health Authority portfolio CI