{"id":"chloroprocaine-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Allergic reactions (rare with ester metabolites)"},{"rate":null,"effect":"Systemic toxicity (with overdose)"},{"rate":null,"effect":"Local tissue irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chloroprocaine is an ester-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks the generation and propagation of action potentials in sensory, motor, and autonomic nerves. It has a rapid onset and short duration of action, making it suitable for infiltration anesthesia and nerve blocks.","oneSentence":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:01.919Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia"},{"name":"Peripheral nerve blocks"},{"name":"Dental anesthesia"}]},"trialDetails":[{"nctId":"NCT03918798","phase":"PHASE2","title":"The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2019-02-14","conditions":"Hernia, Inguinal, Flat Foot","enrollment":164},{"nctId":"NCT07456826","phase":"PHASE4","title":"Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections","status":"NOT_YET_RECRUITING","sponsor":"Harrow Inc","startDate":"2026-04","conditions":"Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD), Retinal Vein Occlusion","enrollment":236},{"nctId":"NCT07444827","phase":"PHASE4","title":"Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-07-01","conditions":"Anesthesia, Local","enrollment":25},{"nctId":"NCT07239999","phase":"PHASE4","title":"Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Nova Scotia Health Authority","startDate":"2026-03-31","conditions":"Recovery Period, Anesthesia","enrollment":170},{"nctId":"NCT07348614","phase":"PHASE4","title":"Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-03","conditions":"Knee Stiffness After Total Knee Arthroplasty","enrollment":128},{"nctId":"NCT06376058","phase":"NA","title":"Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section","status":"RECRUITING","sponsor":"Aretaieion University Hospital","startDate":"2024-01-10","conditions":"Cesarean Section, Local Anesthetic","enrollment":60},{"nctId":"NCT03967288","phase":"PHASE4","title":"Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery","status":"SUSPENDED","sponsor":"Oregon Health and Science University","startDate":"2019-10-24","conditions":"Anesthesia, Spinal","enrollment":27},{"nctId":"NCT02919072","phase":"PHASE3","title":"Chloroprocaine 3% - 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Used for Local infiltration anesthesia, Peripheral nerve blocks, Dental anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}