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Chlorhexidine Topical Cream
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Skin antisepsis and wound disinfection, Prevention of bacterial infection in minor cuts, abrasions, and burns, Topical antimicrobial for skin preparation before procedures.
At a glance
| Generic name | Chlorhexidine Topical Cream |
|---|---|
| Sponsor | Sheikh Zayed Federal Postgraduate Medical Institute |
| Drug class | Antimicrobial/Antiseptic agent |
| Modality | Small molecule |
| Therapeutic area | Dermatology/Infection Prevention |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine works by binding to and disrupting the cell membranes of bacteria, fungi, and some viruses, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. As a topical cream formulation, it provides localized antimicrobial activity on the skin surface and in superficial wounds.
Approved indications
- Skin antisepsis and wound disinfection
- Prevention of bacterial infection in minor cuts, abrasions, and burns
- Topical antimicrobial for skin preparation before procedures
Common side effects
- Local skin irritation
- Contact dermatitis
- Allergic sensitization
- Rash
Key clinical trials
- Topical Steroids & Bacterial Decolonization for Radiation Dermatitis (PHASE2)
- A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns (PHASE2)
- The Study on Bacterial Load Following Open-to-air Management in Burn Patients. (NA)
- An Accessible Low-cost Plant Treatment for Cutaneous Ulcers (PHASE2)
- Use of Nile Tilapia Fish Skin as a Xenograft for Burn Treatment: Phase III Study (PHASE3)
- A Trial Assessing Efficacy of Various Antimicrobial Techniques for Reducing Bacterial Load (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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