{"id":"chlorhexidine-topical-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Allergic sensitization"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL1628","moleculeType":"Small molecule","molecularWeight":"701.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine works by binding to and disrupting the cell membranes of bacteria, fungi, and some viruses, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. As a topical cream formulation, it provides localized antimicrobial activity on the skin surface and in superficial wounds.","oneSentence":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:18:06.800Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis and wound disinfection"},{"name":"Prevention of bacterial infection in minor cuts, abrasions, and burns"},{"name":"Topical antimicrobial for skin preparation before procedures"}]},"trialDetails":[{"nctId":"NCT05505214","phase":"PHASE2","title":"Topical Steroids & Bacterial Decolonization for Radiation Dermatitis","status":"WITHDRAWN","sponsor":"Montefiore Medical Center","startDate":"2023-09-01","conditions":"Radiation Dermatitis","enrollment":""},{"nctId":"NCT06002295","phase":"PHASE2","title":"A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns","status":"COMPLETED","sponsor":"Sheikh Zayed Federal Postgraduate Medical Institute","startDate":"2020-09-12","conditions":"Neonatal Sepsis, Omphalitis","enrollment":300},{"nctId":"NCT04502914","phase":"NA","title":"The Study on Bacterial Load Following Open-to-air Management in Burn Patients.","status":"WITHDRAWN","sponsor":"Texas Tech University Health Sciences Center","startDate":"2020-11-01","conditions":"Burns, Infection Wound, Bacterial Infections","enrollment":""},{"nctId":"NCT04453124","phase":"PHASE2","title":"An Accessible Low-cost Plant Treatment for Cutaneous Ulcers","status":"COMPLETED","sponsor":"Oriol Mitja","startDate":"2019-11-01","conditions":"Yaws; Cutaneous, Cutaneous Ulcer, Yaws","enrollment":150},{"nctId":"NCT04202289","phase":"PHASE3","title":"Use of Nile Tilapia Fish Skin as a Xenograft for Burn Treatment: Phase III Study","status":"COMPLETED","sponsor":"Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara","startDate":"2017-04-03","conditions":"Burns","enrollment":115},{"nctId":"NCT02391077","phase":"PHASE1","title":"A Trial Assessing Efficacy of Various Antimicrobial Techniques for Reducing Bacterial Load","status":"UNKNOWN","sponsor":"Ministry of Health, Rwanda","startDate":"2015-04","conditions":"Disease Due to Gram-positive Bacteria","enrollment":33}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Chlorhexidine Topical Cream","genericName":"Chlorhexidine Topical Cream","companyName":"Sheikh Zayed Federal Postgraduate Medical Institute","companyId":"sheikh-zayed-federal-postgraduate-medical-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Skin antisepsis and wound disinfection, Prevention of bacterial infection in minor cuts, abrasions, and burns, Topical antimicrobial for skin preparation before procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}