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Chlorhexidine oral care
Chlorhexidine is an antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing broad-spectrum antimicrobial activity for oral care.
Chlorhexidine is an antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing broad-spectrum antimicrobial activity for oral care. Used for Oral hygiene and plaque control, Prevention and treatment of gingivitis, Antimicrobial oral rinse.
At a glance
| Generic name | Chlorhexidine oral care |
|---|---|
| Sponsor | University of Pavia |
| Drug class | Antimicrobial agent / Antiseptic |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also precipitates bacterial proteins and nucleic acids. In oral care formulations, it reduces pathogenic oral bacteria and helps prevent plaque formation and gingivitis.
Approved indications
- Oral hygiene and plaque control
- Prevention and treatment of gingivitis
- Antimicrobial oral rinse
Common side effects
- Tooth staining
- Taste alteration
- Oral irritation
- Calculus buildup
Key clinical trials
- PMPR and Chlorhexidine on Periodontal Disease and Vascular Function (NA)
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash (EARLY_PHASE1)
- Oropharyngeal Care With Colostrum, Chlorohexidine and Sodium Bicarbonate in Preventing Ventilator-associated Pneumonia in Preterm Neonates (NA)
- Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid (NA)
- Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib (PHASE2)
- Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes (NA)
- Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation (NA)
- Oral Hygiene and Prophylactic Antibiotics to Prevent Intracerebral Hemorrhage Associated Pneumonia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorhexidine oral care CI brief — competitive landscape report
- Chlorhexidine oral care updates RSS · CI watch RSS
- University of Pavia portfolio CI