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Chlorhexidine Digluconate Mouthwash without Alcohol
Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, killing or inhibiting growth of oral microorganisms.
Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, killing or inhibiting growth of oral microorganisms. Used for Prevention and treatment of gingivitis, Reduction of plaque formation, Oral antisepsis and antimicrobial rinse.
At a glance
| Generic name | Chlorhexidine Digluconate Mouthwash without Alcohol |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Antimicrobial oral rinse |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell surfaces, causing leakage of cellular contents and cell death. It is bactericidal at higher concentrations and bacteriostatic at lower concentrations, with activity against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The alcohol-free formulation maintains antimicrobial efficacy while improving tolerability for patients who cannot use alcohol-containing rinses.
Approved indications
- Prevention and treatment of gingivitis
- Reduction of plaque formation
- Oral antisepsis and antimicrobial rinse
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or burning sensation
- Calculus buildup
- Allergic reactions (rare)
Key clinical trials
- Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
- Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars (NA)
- Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis (NA)
- Pre-procedural Mouthwash in Reducing Bacteria in Dental Aerosols (PHASE3)
- Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7% (PHASE3)
- Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth (PHASE4)
- Microsurgical Versus Conventional Semilunar Coronally Advanced Flap (PHASE4)
- An Efficacy Study of Chlorhexidine Mouthwashes (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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