{"id":"chlorhexidine-digluconate-mouthwash-without-alcohol","safety":{"commonSideEffects":[{"rate":"15-30","effect":"Tooth staining (brown discoloration)"},{"rate":"5-15","effect":"Taste alteration"},{"rate":"5-10","effect":"Oral irritation or burning sensation"},{"rate":"5-10","effect":"Calculus buildup"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":{"chemblId":"CHEMBL1628","moleculeType":"Small molecule","molecularWeight":"701.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell surfaces, causing leakage of cellular contents and cell death. It is bactericidal at higher concentrations and bacteriostatic at lower concentrations, with activity against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The alcohol-free formulation maintains antimicrobial efficacy while improving tolerability for patients who cannot use alcohol-containing rinses.","oneSentence":"Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, killing or inhibiting growth of oral microorganisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:21.863Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of gingivitis"},{"name":"Reduction of plaque formation"},{"name":"Oral antisepsis and antimicrobial rinse"}]},"trialDetails":[{"nctId":"NCT06378359","phase":"","title":"Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2024-01-29","conditions":"Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections","enrollment":250},{"nctId":"NCT06880952","phase":"NA","title":"Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars","status":"COMPLETED","sponsor":"Isala","startDate":"2021-09-01","conditions":"Third Molars Extraction","enrollment":145},{"nctId":"NCT04733196","phase":"NA","title":"Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis","status":"COMPLETED","sponsor":"Plovdiv Medical University","startDate":"2020-10-01","conditions":"Gingivitis","enrollment":180},{"nctId":"NCT02875769","phase":"PHASE3","title":"Pre-procedural Mouthwash in Reducing Bacteria in Dental Aerosols","status":"COMPLETED","sponsor":"University of Guarulhos","startDate":"2015-02","conditions":"Chronic Periodontitis","enrollment":60},{"nctId":"NCT02414581","phase":"PHASE3","title":"Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7%","status":"COMPLETED","sponsor":"Hospital Regional de Alta Especialidad del Bajio","startDate":"2015-04","conditions":"Neutropenia","enrollment":60},{"nctId":"NCT02946801","phase":"PHASE4","title":"Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth","status":"UNKNOWN","sponsor":"University of Santiago de Compostela","startDate":"2016-11","conditions":"Biofilms, Oils, Essential, Periodontitis","enrollment":20},{"nctId":"NCT02433899","phase":"PHASE4","title":"Microsurgical Versus Conventional Semilunar Coronally Advanced Flap","status":"COMPLETED","sponsor":"Universidade Federal Fluminense","startDate":"2010-10","conditions":"Gingival Recession","enrollment":14},{"nctId":"NCT01751178","phase":"PHASE4","title":"An Efficacy Study of Chlorhexidine Mouthwashes","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-10","conditions":"Gingivitis","enrollment":324}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":292,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Chlorhexidine Digluconate Mouthwash without Alcohol","genericName":"Chlorhexidine Digluconate Mouthwash without Alcohol","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, killing or inhibiting growth of oral microorganisms. Used for Prevention and treatment of gingivitis, Reduction of plaque formation, Oral antisepsis and antimicrobial rinse.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}