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Chlorhexidine 0.2% Mouthrinse
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load.
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load. Used for Oral antimicrobial rinse for plaque and gingivitis reduction, Oral hygiene maintenance and prevention of dental caries.
At a glance
| Generic name | Chlorhexidine 0.2% Mouthrinse |
|---|---|
| Also known as | Corsodyl 0.2% Chlorhexidine mouthwash |
| Sponsor | University of Oslo |
| Drug class | Antimicrobial agent / Antiseptic |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also precipitates bacterial proteins and nucleic acids. At the 0.2% concentration used in mouthrinse formulations, it provides rapid and sustained antimicrobial activity against a wide range of gram-positive and gram-negative oral bacteria.
Approved indications
- Oral antimicrobial rinse for plaque and gingivitis reduction
- Oral hygiene maintenance and prevention of dental caries
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or burning sensation
- Increased calculus formation
Key clinical trials
- To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. (NA)
- Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren (NA)
- Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices (NA)
- Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis (NA)
- Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk (NA)
- Periodontal Wound Healing With CHX and Hyaluronic Acid (NA)
- Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity (PHASE4)
- Interaction Between Chlorhexidine and Fluoride (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorhexidine 0.2% Mouthrinse CI brief — competitive landscape report
- Chlorhexidine 0.2% Mouthrinse updates RSS · CI watch RSS
- University of Oslo portfolio CI