{"id":"chlorhexidine-0-2-mouthrinse","safety":{"commonSideEffects":[{"rate":"5-30","effect":"Tooth staining (brown discoloration)"},{"rate":"5-15","effect":"Taste alteration"},{"rate":"1-5","effect":"Oral irritation or burning sensation"},{"rate":"5-10","effect":"Increased calculus formation"}]},"_chembl":{"chemblId":"CHEMBL1628","moleculeType":"Small molecule","molecularWeight":"701.61"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also precipitates bacterial proteins and nucleic acids. At the 0.2% concentration used in mouthrinse formulations, it provides rapid and sustained antimicrobial activity against a wide range of gram-positive and gram-negative oral bacteria.","oneSentence":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:21.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antimicrobial rinse for plaque and gingivitis reduction"},{"name":"Oral hygiene maintenance and prevention of dental caries"}]},"trialDetails":[{"nctId":"NCT07191262","phase":"NA","title":"To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-03-02","conditions":"Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth","enrollment":40},{"nctId":"NCT07309679","phase":"NA","title":"Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2023-03-07","conditions":"Plaque Score, Gingival Health, Streptococcus Mutans","enrollment":156},{"nctId":"NCT07307716","phase":"NA","title":"Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices","status":"NOT_YET_RECRUITING","sponsor":"Riyadh Elm University","startDate":"2026-02","conditions":"Gingivitis, Dental Plaque","enrollment":21},{"nctId":"NCT06967402","phase":"NA","title":"Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-07","conditions":"Periodontitis, Periodontitis Stage II, Periodontitis Stage III","enrollment":60},{"nctId":"NCT03513575","phase":"NA","title":"Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk","status":"COMPLETED","sponsor":"Dr Meru S","startDate":"2018-05-01","conditions":"Saliva Altered, Oral Hygiene, pH","enrollment":30},{"nctId":"NCT03465670","phase":"NA","title":"Periodontal Wound Healing With CHX and Hyaluronic Acid","status":"COMPLETED","sponsor":"University Hospital of Ferrara","startDate":"2015-12-16","conditions":"Surgical Flaps, Wound Healing, Gingiva","enrollment":37},{"nctId":"NCT02319668","phase":"PHASE4","title":"Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-02-01","conditions":"Dental Prophylaxis and Implant Surgery","enrollment":38},{"nctId":"NCT02935322","phase":"PHASE4","title":"Interaction Between Chlorhexidine and Fluoride","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2009-09","conditions":"Periodontal Disease, Dental Caries","enrollment":32},{"nctId":"NCT02911766","phase":"PHASE4","title":"Efficacy of Different Chlorhexidine Concentrations","status":"UNKNOWN","sponsor":"University of Oslo","startDate":"2016-11","conditions":"Dental Plaque, Gingivitis","enrollment":59},{"nctId":"NCT01580943","phase":"PHASE1, PHASE2","title":"Efficacy of Two Commercially Available Chlorhexidine Mouthrinses Non-alcohol Base","status":"COMPLETED","sponsor":"Universidade do Porto","startDate":"2011-10","conditions":"Dental Plaque","enrollment":50},{"nctId":"NCT01255254","phase":"PHASE1","title":"The Effect of Oral Hygiene and Full Mouth Scaling on Metabolic Control in Patients With Type II Diabetes","status":"UNKNOWN","sponsor":"Rambam Health Care Campus","startDate":"2010-08","conditions":"Gingival Scaling, Metabolic Control","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Corsodyl 0.2% Chlorhexidine mouthwash"],"phase":"marketed","status":"active","brandName":"Chlorhexidine 0.2% Mouthrinse","genericName":"Chlorhexidine 0.2% Mouthrinse","companyName":"University of Oslo","companyId":"university-of-oslo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load. Used for Oral antimicrobial rinse for plaque and gingivitis reduction, Oral hygiene maintenance and prevention of dental caries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}