Last reviewed 2026-04-22 · How we verify

Chlorhexidine 0.2%, Curasept

Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.

Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Oral antisepsis and plaque control, Prevention of gingivitis and periodontal disease, Oral rinse for antimicrobial purposes.

At a glance

Mechanism of action

Chlorhexidine works by binding to and disrupting the integrity of bacterial cell membranes, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. At the 0.2% concentration in Curasept, it is effective against a wide range of gram-positive and gram-negative bacteria, making it suitable for oral antisepsis and plaque control.

Approved indications

• Oral antisepsis and plaque control
• Prevention of gingivitis and periodontal disease
• Oral rinse for antimicrobial purposes

Common side effects

• Tooth staining (brown discoloration)
• Taste alteration
• Oral irritation or burning sensation
• Increased calculus formation

Key clinical trials

• Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath (NA)
• Clinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Chlorhexidine 0.2%, Curasept CI brief — competitive landscape report
• Chlorhexidine 0.2%, Curasept updates RSS · CI watch RSS
• University of Oslo portfolio CI