{"id":"chlorhexidine-0-2-curasept","safety":{"commonSideEffects":[{"rate":"5-30","effect":"Tooth staining (brown discoloration)"},{"rate":"5-15","effect":"Taste alteration"},{"rate":"1-5","effect":"Oral irritation or burning sensation"},{"rate":"null","effect":"Increased calculus formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine works by binding to and disrupting the integrity of bacterial cell membranes, leading to leakage of cellular contents and cell death. It also denatures bacterial proteins and interferes with metabolic processes. At the 0.2% concentration in Curasept, it is effective against a wide range of gram-positive and gram-negative bacteria, making it suitable for oral antisepsis and plaque control.","oneSentence":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:00.935Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antisepsis and plaque control"},{"name":"Prevention of gingivitis and periodontal disease"},{"name":"Oral rinse for antimicrobial purposes"}]},"trialDetails":[{"nctId":"NCT06219226","phase":"NA","title":"Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath","status":"ENROLLING_BY_INVITATION","sponsor":"Semmelweis University","startDate":"2024-04-18","conditions":"Halitosis","enrollment":60},{"nctId":"NCT04223076","phase":"PHASE4","title":"Clinical Effect of Chlorhexidine Mouthwash After Periodontal Surgery","status":"UNKNOWN","sponsor":"University of Oslo","startDate":"2019-03-20","conditions":"Periodontal Diseases, Periodontitis, Dental Plaque","enrollment":31}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Chlorhexidine 0.2%, Curasept","genericName":"Chlorhexidine 0.2%, Curasept","companyName":"University of Oslo","companyId":"university-of-oslo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing antiseptic and disinfectant effects. Used for Oral antisepsis and plaque control, Prevention of gingivitis and periodontal disease, Oral rinse for antimicrobial purposes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}