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Chirocaine ketorolac epinephrine
Chirocaine ketorolac epinephrine is a Local anesthetic combination with NSAID and vasopressor Small molecule drug developed by maximiliano barahona vasquez. It is currently in Phase 3 development for Local anesthesia and hemostasis during surgical procedures, Perioperative pain management.
This combination drug provides local anesthesia via chirocaine, reduces inflammation and pain via ketorolac, and enhances vasoconstriction and hemostasis via epinephrine.
This combination drug provides local anesthesia via chirocaine, reduces inflammation and pain via ketorolac, and enhances vasoconstriction and hemostasis via epinephrine. Used for Local anesthesia and hemostasis during surgical procedures, Perioperative pain management.
At a glance
| Generic name | Chirocaine ketorolac epinephrine |
|---|---|
| Sponsor | maximiliano barahona vasquez |
| Drug class | Local anesthetic combination with NSAID and vasopressor |
| Target | Voltage-gated sodium channels (chirocaine); COX-1/COX-2 (ketorolac); alpha-1 and beta-adrenergic receptors (epinephrine) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Surgery, Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Chirocaine (levobupivacaine) is a local anesthetic that blocks sodium channels in nerve fibers. Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin-mediated pain and inflammation. Epinephrine acts as an alpha and beta-adrenergic agonist to cause vasoconstriction, reducing bleeding and prolonging the duration of local anesthesia.
Approved indications
- Local anesthesia and hemostasis during surgical procedures
- Perioperative pain management
Common side effects
- Hypertension
- Tachycardia
- Gastrointestinal bleeding or ulceration (ketorolac-related)
- Renal impairment (ketorolac-related)
- Local tissue irritation or necrosis
- Allergic reaction
Key clinical trials
- Efficacy of Adrenaline in Periarticular Analgesic Injection on Postoperative Pain Control After Total Knee Arthroplasty (PHASE2)
- Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty (PHASE3)
- The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA (PHASE4)
- Local Infiltration Analgesia During Total Knee Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chirocaine ketorolac epinephrine CI brief — competitive landscape report
- Chirocaine ketorolac epinephrine updates RSS · CI watch RSS
- maximiliano barahona vasquez portfolio CI
Frequently asked questions about Chirocaine ketorolac epinephrine
What is Chirocaine ketorolac epinephrine?
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Who makes Chirocaine ketorolac epinephrine?
What drug class is Chirocaine ketorolac epinephrine in?
What development phase is Chirocaine ketorolac epinephrine in?
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What does Chirocaine ketorolac epinephrine target?
Related
- Drug class: All Local anesthetic combination with NSAID and vasopressor drugs
- Target: All drugs targeting Voltage-gated sodium channels (chirocaine); COX-1/COX-2 (ketorolac); alpha-1 and beta-adrenergic receptors (epinephrine)
- Manufacturer: maximiliano barahona vasquez — full pipeline
- Therapeutic area: All drugs in Pain Management, Surgery, Anesthesia
- Indication: Drugs for Local anesthesia and hemostasis during surgical procedures
- Indication: Drugs for Perioperative pain management
- Compare: Chirocaine ketorolac epinephrine vs similar drugs
- Pricing: Chirocaine ketorolac epinephrine cost, discount & access