Last reviewed · How we verify
Celebrex, acetaminophen, and dexamethasone
This combination reduces pain and inflammation through COX inhibition (Celebrex), blocks pain signal transmission (acetaminophen), and suppresses immune-mediated inflammation (dexamethasone).
This combination reduces pain and inflammation through COX inhibition (Celebrex), blocks pain signal transmission (acetaminophen), and suppresses immune-mediated inflammation (dexamethasone). Used for Pain and inflammation management (specific indication unclear from phase 3 context).
At a glance
| Generic name | Celebrex, acetaminophen, and dexamethasone |
|---|---|
| Also known as | Pharmacological |
| Sponsor | Gangnam Severance Hospital |
| Drug class | Combination analgesic and anti-inflammatory |
| Target | COX-2, TRPV1 (acetaminophen), glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Rheumatology, Inflammation |
| Phase | Phase 3 |
Mechanism of action
Celebrex (celecoxib) is a selective COX-2 inhibitor that reduces prostaglandin production. Acetaminophen works through central analgesic and antipyretic mechanisms. Dexamethasone is a corticosteroid that broadly suppresses inflammatory and immune responses. Together, they provide multi-modal pain and inflammation control.
Approved indications
- Pain and inflammation management (specific indication unclear from phase 3 context)
Common side effects
- Gastrointestinal upset
- Hepatotoxicity (acetaminophen)
- Immunosuppression (dexamethasone)
- Cardiovascular risk (celecoxib)
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy (PHASE2)
- Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery (PHASE3)
- Pre vs Post Block in Total Knee Arthroplasty (TKA) (PHASE4)
- Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty (PHASE4)
- Multimodal Analgesia for Cholecystectomy (PHASE3)
- Factors Affecting the Speed of Recovery After ACL Reconstruction (NA)
- Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: