{"id":"celebrex-acetaminophen-and-dexamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen)"},{"rate":null,"effect":"Immunosuppression (dexamethasone)"},{"rate":null,"effect":"Cardiovascular risk (celecoxib)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Celebrex (celecoxib) is a selective COX-2 inhibitor that reduces prostaglandin production. Acetaminophen works through central analgesic and antipyretic mechanisms. Dexamethasone is a corticosteroid that broadly suppresses inflammatory and immune responses. Together, they provide multi-modal pain and inflammation control.","oneSentence":"This combination reduces pain and inflammation through COX inhibition (Celebrex), blocks pain signal transmission (acetaminophen), and suppresses immune-mediated inflammation (dexamethasone).","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:44:09.372Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain and inflammation management (specific indication unclear from phase 3 context)"}]},"trialDetails":[{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":"Shoulder Arthropathy, Shoulder Pain","enrollment":83},{"nctId":"NCT05017246","phase":"PHASE2","title":"Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy","status":"TERMINATED","sponsor":"Washington University School of Medicine","startDate":"2022-01-18","conditions":"Cancer Debulking, Enlarged Uterus, Fibroid Uterus","enrollment":110},{"nctId":"NCT05965492","phase":"PHASE3","title":"Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2024-06-01","conditions":"Spinal Disorder","enrollment":""},{"nctId":"NCT05974501","phase":"PHASE4","title":"Pre vs Post Block in Total Knee Arthroplasty (TKA)","status":"COMPLETED","sponsor":"University of Miami","startDate":"2023-09-29","conditions":"Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain","enrollment":84},{"nctId":"NCT03859024","phase":"PHASE4","title":"Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2019-03-22","conditions":"Pain, Postoperative, Urethral Stricture","enrollment":48},{"nctId":"NCT04788654","phase":"PHASE3","title":"Multimodal Analgesia for Cholecystectomy","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2021-03-17","conditions":"Laparoscopic Cholecystectomy","enrollment":60},{"nctId":"NCT03770806","phase":"NA","title":"Factors Affecting the Speed of Recovery After ACL Reconstruction","status":"COMPLETED","sponsor":"University of Washington","startDate":"2017-03-24","conditions":"Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture","enrollment":48},{"nctId":"NCT02160301","phase":"PHASE4","title":"Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients","status":"WITHDRAWN","sponsor":"University of North Carolina, Chapel Hill","startDate":"2017-11","conditions":"Post Operative Pain Control","enrollment":""},{"nctId":"NCT02110719","phase":"PHASE4","title":"Decreasing Narcotics in Advanced Pelvic Surgery","status":"COMPLETED","sponsor":"Hartford Hospital","startDate":"2014-03","conditions":"Narcotic Use, Pain, Constipation","enrollment":138}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pharmacological"],"phase":"phase_3","status":"active","brandName":"Celebrex, acetaminophen, and dexamethasone","genericName":"Celebrex, acetaminophen, and dexamethasone","companyName":"Gangnam Severance Hospital","companyId":"gangnam-severance-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces pain and inflammation through COX inhibition (Celebrex), blocks pain signal transmission (acetaminophen), and suppresses immune-mediated inflammation (dexamethasone). Used for Pain and inflammation management (specific indication unclear from phase 3 context).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}