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CCRT arm without consolidation chemotherapy
CCRT (concurrent chemoradiation therapy) without consolidation chemotherapy is a treatment regimen that combines chemotherapy and radiation therapy simultaneously, followed by observation without additional chemotherapy cycles.
CCRT (concurrent chemoradiation therapy) without consolidation chemotherapy is a treatment regimen that combines chemotherapy and radiation therapy simultaneously, followed by observation without additional chemotherapy cycles. Used for Locally advanced cancer (specific histology not specified in provided information).
At a glance
| Generic name | CCRT arm without consolidation chemotherapy |
|---|---|
| Sponsor | Samsung Medical Center |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
This is a clinical trial treatment approach rather than a single drug entity. CCRT delivers chemotherapy and radiation concurrently to enhance local tumor control, with the rationale that omitting post-treatment consolidation chemotherapy may reduce toxicity while maintaining efficacy. The mechanism relies on radiosensitization by concurrent chemotherapy and direct cytotoxic effects of both modalities.
Approved indications
- Locally advanced cancer (specific histology not specified in provided information)
Common side effects
- Radiation dermatitis
- Esophagitis
- Hematologic toxicity
- Nausea and vomiting
Key clinical trials
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |