{"id":"ccrt-arm-without-consolidation-chemotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Radiation dermatitis"},{"rate":null,"effect":"Esophagitis"},{"rate":null,"effect":"Hematologic toxicity"},{"rate":null,"effect":"Nausea and vomiting"}]},"_chembl":{"chemblId":"CHEMBL3896316","moleculeType":"Small molecule","molecularWeight":"654.59"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a clinical trial treatment approach rather than a single drug entity. CCRT delivers chemotherapy and radiation concurrently to enhance local tumor control, with the rationale that omitting post-treatment consolidation chemotherapy may reduce toxicity while maintaining efficacy. The mechanism relies on radiosensitization by concurrent chemotherapy and direct cytotoxic effects of both modalities.","oneSentence":"CCRT (concurrent chemoradiation therapy) without consolidation chemotherapy is a treatment regimen that combines chemotherapy and radiation therapy simultaneously, followed by observation without additional chemotherapy cycles.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:05:01.956Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Locally advanced cancer (specific histology not specified in provided information)"}]},"trialDetails":[{"nctId":"NCT00326378","phase":"PHASE3","title":"Efficacy Study of Additional Chemotherapy After Concurrent Chemoradiation in Non-small Cell Lung Cancer","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2005-10","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":434}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"CCRT arm without consolidation chemotherapy","genericName":"CCRT arm without consolidation chemotherapy","companyName":"Samsung Medical Center","companyId":"samsung-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CCRT (concurrent chemoradiation therapy) without consolidation chemotherapy is a treatment regimen that combines chemotherapy and radiation therapy simultaneously, followed by observation without additional chemotherapy cycles. Used for Locally advanced cancer (specific histology not specified in provided information).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}