Last reviewed 2026-04-23 · How we verify

carvedilol immediate release

Carvedilol immediate release is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and by slowing the heart rate and reducing its workload.

Carvedilol immediate release is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and by slowing the heart rate and reducing its workload. Used for Hypertension, Heart failure.

At a glance

Mechanism of action

Carvedilol immediate release is a non-selective beta-blocker that also has alpha-1 adrenergic blocking activity. This allows it to reduce blood pressure and heart rate, while also reducing the workload on the heart.

Approved indications

• Hypertension
• Heart failure

Common side effects

• Dizziness
• Fatigue
• Headache
• Nausea
• Diarrhea

Key clinical trials

• A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure (PHASE3)
• A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure (PHASE1)
• Immediate Release Versus Slow Release Carvedilol in Heart Failure (PHASE4)
• A Study in Healthy Volunteers to Evaluate the Application of Stable Isotope Approach to Reduce Number of Subjects Needed for PK Studies (PHASE1)
• A Study of Controlled-Release Carvedilol Compared to Immediate-Release Carvedilol in Patients With Primary Hypertension (PHASE2)
• Coreg and HSRs-Updated Analysis
• Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg (PHASE3)
• Use of Beta-blockers and Risk of New Onset Diabetes

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.