{"id":"carvedilol-immediate-release","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"10-20%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Diarrhea"}]},"_chembl":null,"_fixedAt":"2026-03-30T13:33:14.753071","_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Carvedilol immediate release is a non-selective beta-blocker that also has alpha-1 adrenergic blocking activity. This allows it to reduce blood pressure and heart rate, while also reducing the workload on the heart.","oneSentence":"Carvedilol immediate release is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and by slowing the heart rate and reducing its workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:59.182Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure"}]},"_fixedFields":["modality→Biologic"],"trialDetails":[{"nctId":"NCT00323037","phase":"PHASE3","title":"A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure","status":"COMPLETED","sponsor":"CTI-1, LLC","startDate":"2006-03","conditions":"Congestive Heart Failure","enrollment":318},{"nctId":"NCT00742508","phase":"PHASE1","title":"A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-08-28","conditions":"Heart Failure, Congestive","enrollment":41},{"nctId":"NCT03209180","phase":"PHASE4","title":"Immediate Release Versus Slow Release Carvedilol in Heart Failure","status":"UNKNOWN","sponsor":"Seoul National University Bundang Hospital","startDate":"2016-10-27","conditions":"Heart Failure With Reduced Ejection Fraction","enrollment":320},{"nctId":"NCT01793870","phase":"PHASE1","title":"A Study in Healthy Volunteers to Evaluate the Application of Stable Isotope Approach to Reduce Number of Subjects Needed for PK Studies","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2013-01-15","conditions":"Metabolic, Cardiovascular","enrollment":17},{"nctId":"NCT00444834","phase":"PHASE2","title":"A Study of Controlled-Release Carvedilol Compared to Immediate-Release Carvedilol in Patients With Primary Hypertension","status":"TERMINATED","sponsor":"Egalet Ltd","startDate":"2007-04","conditions":"Hypertension","enrollment":14},{"nctId":"NCT01316952","phase":"","title":"Coreg and HSRs-Updated Analysis","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-06","conditions":"Hypersensitivity","enrollment":1},{"nctId":"NCT00272805","phase":"PHASE3","title":"Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg","status":"COMPLETED","sponsor":"Cardiovascular Clinical Sciences Inc","startDate":"2005-10","conditions":"Chronic Heart Failure","enrollment":400},{"nctId":"NCT01587638","phase":"","title":"Use of Beta-blockers and Risk of New Onset Diabetes","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-04","conditions":"Hypertension","enrollment":12336}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Coreg","Coreg IR"],"phase":"phase_3","status":"active","brandName":"carvedilol immediate release","genericName":"carvedilol immediate release","companyName":"CTI-1, LLC","companyId":"cti-1-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carvedilol immediate release is a beta-blocker that works by blocking the effects of the hormone epinephrine, also known as adrenaline, and by slowing the heart rate and reducing its workload. Used for Hypertension, Heart failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}