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carbamazepine oxcarbazepine

Odense University Hospital · FDA-approved active Small molecule

carbamazepine oxcarbazepine is a Anticonvulsant / Antiepileptic agent Small molecule drug developed by Odense University Hospital. It is currently FDA-approved for Partial-onset seizures (monotherapy and adjunctive therapy), Generalized tonic-clonic seizures (adjunctive therapy), Bipolar disorder (off-label use).

Oxcarbazepine blocks voltage-gated sodium channels to reduce neuronal excitability and prevent seizure propagation.

Oxcarbazepine blocks voltage-gated sodium channels to reduce neuronal excitability and prevent seizure propagation. Used for Partial-onset seizures (monotherapy and adjunctive therapy), Generalized tonic-clonic seizures (adjunctive therapy), Bipolar disorder (off-label use).

At a glance

Generic namecarbamazepine oxcarbazepine
SponsorOdense University Hospital
Drug classAnticonvulsant / Antiepileptic agent
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaNeurology
PhaseFDA-approved

Mechanism of action

Oxcarbazepine is a keto-analogue of carbamazepine that stabilizes inactivated sodium channels, limiting repetitive neuronal firing. It also modulates high-voltage-activated calcium channels. These actions reduce the spread of seizure activity across neural networks, making it effective for seizure control.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about carbamazepine oxcarbazepine

What is carbamazepine oxcarbazepine?

carbamazepine oxcarbazepine is a Anticonvulsant / Antiepileptic agent drug developed by Odense University Hospital, indicated for Partial-onset seizures (monotherapy and adjunctive therapy), Generalized tonic-clonic seizures (adjunctive therapy), Bipolar disorder (off-label use).

How does carbamazepine oxcarbazepine work?

Oxcarbazepine blocks voltage-gated sodium channels to reduce neuronal excitability and prevent seizure propagation.

What is carbamazepine oxcarbazepine used for?

carbamazepine oxcarbazepine is indicated for Partial-onset seizures (monotherapy and adjunctive therapy), Generalized tonic-clonic seizures (adjunctive therapy), Bipolar disorder (off-label use).

Who makes carbamazepine oxcarbazepine?

carbamazepine oxcarbazepine is developed and marketed by Odense University Hospital (see full Odense University Hospital pipeline at /company/odense-university-hospital).

What drug class is carbamazepine oxcarbazepine in?

carbamazepine oxcarbazepine belongs to the Anticonvulsant / Antiepileptic agent class. See all Anticonvulsant / Antiepileptic agent drugs at /class/anticonvulsant-antiepileptic-agent.

What development phase is carbamazepine oxcarbazepine in?

carbamazepine oxcarbazepine is FDA-approved (marketed).

What are the side effects of carbamazepine oxcarbazepine?

Common side effects of carbamazepine oxcarbazepine include Dizziness, Somnolence, Headache, Ataxia, Diplopia, Nausea.

What does carbamazepine oxcarbazepine target?

carbamazepine oxcarbazepine targets Voltage-gated sodium channels and is a Anticonvulsant / Antiepileptic agent.

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