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Calcium Ionophore A23187
Calcium ionophore A23187 facilitates the transport of calcium ions across cell membranes, increasing intracellular calcium concentration.
At a glance
| Generic name | Calcium Ionophore A23187 |
|---|---|
| Also known as | non |
| Sponsor | MOHAMED BEHERY |
| Drug class | Calcium ionophore |
| Target | Calcium ion (Ca2+) transport across cell membranes |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
A23187 is a lipophilic ionophore that binds calcium ions and shuttles them across the lipid bilayer of cell membranes, bypassing normal calcium channels. This artificial elevation of intracellular calcium triggers downstream signaling cascades and cellular responses. It is primarily used as a research tool and laboratory reagent rather than a therapeutic agent.
Approved indications
Common side effects
Key clinical trials
- Live Birth Rate Between ICSI and AOA and ICSI Alone in Patients With Severe Teratospermia (NA)
- Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore. (NA)
- AOA in Recurrent Fertilization Failure (PHASE4)
- Artificial Assisted Activation Following in Fertilization Failure (NA)
- Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART (NA)
- Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility? (PHASE2, PHASE3)
- Effect of Ca2+ Ionophore on Embryonic Development and Clinical Outcome in Cases With Previous Fertilization Arrest (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Calcium Ionophore A23187 CI brief — competitive landscape report
- Calcium Ionophore A23187 updates RSS · CI watch RSS
- MOHAMED BEHERY portfolio CI