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Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore: a Prospective Randomized Study. (Calcifer)
This study is a prospective ranzomized analysis including 372 human oocytes from 44 women. Half of the oocytes from the same patient will be randomly allocated to induce oocyte activation using two protocols: in protocol nº 1 we will use ionomycin (prepared solution), protocol nª2 A23187 (GM508 CultActive Gynemed) will be applied. Non treated oocytes will serve as control. Oocyte fertilization rates, embryo development and embryo quality will be analyzed. Obstetrics variables of offspring will be also followed and compared.
Details
| Lead sponsor | Instituto Valenciano de Infertilidad, IVI VALENCIA |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 44 |
| Start date | 2024-01-01 |
| Completion | 2024-12 |
Conditions
- Infertility, Female
Interventions
- Ionomycin SIGMA
- A23187
Primary outcomes
- Improvement in the percetage of usable blastocyst per injeected oocyte — 1 YEAR
To evaluate which AOA protocol with the use of two calcium (Ca2+) ionophores, ionomycin and A23187 (calcimycin), is better (improvement from 15% to 25%)
Countries
Spain