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Calcium hydroxide intracanal medication application
Calcium hydroxide acts as an intracanal medicament that creates an alkaline environment to disinfect the root canal system and promote healing.
Calcium hydroxide acts as an intracanal medicament that creates an alkaline environment to disinfect the root canal system and promote healing. Used for Intracanal disinfection in endodontic therapy, Root canal treatment as an inter-appointment medicament, Management of infected root canals and periapical pathology.
At a glance
| Generic name | Calcium hydroxide intracanal medication application |
|---|---|
| Sponsor | Suez Canal University |
| Drug class | Intracanal medicament |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Endodontics |
| Phase | FDA-approved |
Mechanism of action
Calcium hydroxide dissociates into calcium and hydroxyl ions, creating a highly alkaline pH (12.5) that has antimicrobial properties against endodontic pathogens and promotes hard tissue formation. It also neutralizes bacterial endotoxins and dissolves necrotic tissue remnants within the root canal space. The medication is placed between appointments to reduce intracanal bacterial load before final obturation.
Approved indications
- Intracanal disinfection in endodontic therapy
- Root canal treatment as an inter-appointment medicament
- Management of infected root canals and periapical pathology
Common side effects
- Periapical inflammation (if extruded beyond apex)
- Allergic reaction (rare)
- Tooth discoloration (with prolonged contact)
Key clinical trials
- Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment (NA)
- Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication . (PHASE4)
- Different Treatment Modality in Necrotic Primary Molars (NA)
- Effect of Low-level Laser Therapy Versus Calcium Hydroxide Intracanal Medication on Postoperative Pain and Substance P Levels in Patients With Symptomatic Apical Periodontitis (NA)
- Clinical & Radiographical Evaluation of the Effect of Dycal & Biodentine in DPC in Primary Teeth (NA)
- Magnetic Resonance Imaging (MRI) of Pulp Regeneration (PHASE2)
- Photodynamic Therapy in Endodontic Treatment (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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