{"id":"calcium-hydroxide-intracanal-medication-application","safety":{"commonSideEffects":[{"rate":null,"effect":"Periapical inflammation (if extruded beyond apex)"},{"rate":null,"effect":"Allergic reaction (rare)"},{"rate":null,"effect":"Tooth discoloration (with prolonged contact)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcium hydroxide dissociates into calcium and hydroxyl ions, creating a highly alkaline pH (12.5) that has antimicrobial properties against endodontic pathogens and promotes hard tissue formation. It also neutralizes bacterial endotoxins and dissolves necrotic tissue remnants within the root canal space. The medication is placed between appointments to reduce intracanal bacterial load before final obturation.","oneSentence":"Calcium hydroxide acts as an intracanal medicament that creates an alkaline environment to disinfect the root canal system and promote healing.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:37.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intracanal disinfection in endodontic therapy"},{"name":"Root canal treatment as an inter-appointment medicament"},{"name":"Management of infected root canals and periapical pathology"}]},"trialDetails":[{"nctId":"NCT07141459","phase":"NA","title":"Efficacy of 810 nm Diode Laser Disinfection on Inflammatory Cytokines and Postoperative Pain After Endodontic Retreatment","status":"RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-08-18","conditions":"Previous Endodontic Treatment Failure and Radiographically Confirmed Periapical Radiolucency","enrollment":52},{"nctId":"NCT05021809","phase":"PHASE4","title":"Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication .","status":"UNKNOWN","sponsor":"Suez Canal University","startDate":"2021-07-25","conditions":"Necrotic Pulp With Symptomatic Apical Periodontitis","enrollment":60},{"nctId":"NCT04190914","phase":"NA","title":"Different Treatment Modality in Necrotic Primary Molars","status":"COMPLETED","sponsor":"dina darwish","startDate":"2020-02-07","conditions":"Primary Teeth, Dental Pulp Regeneration","enrollment":54},{"nctId":"NCT04594317","phase":"NA","title":"Effect of Low-level Laser Therapy Versus Calcium Hydroxide Intracanal Medication on Postoperative Pain and Substance P Levels in Patients With Symptomatic Apical Periodontitis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-02-01","conditions":"Postoperative Pain, Apical Periodontitis","enrollment":46},{"nctId":"NCT02789423","phase":"NA","title":"Clinical & Radiographical Evaluation of the Effect of Dycal & Biodentine in DPC in Primary Teeth","status":"COMPLETED","sponsor":"Modern Dental College and Research Centre, Indore","startDate":"2013-06","conditions":"Dental Pulp Exposure","enrollment":60},{"nctId":"NCT03804450","phase":"PHASE2","title":"Magnetic Resonance Imaging (MRI) of Pulp Regeneration","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2017-07-01","conditions":"Pulp Necroses, Periapical Lesion, Regeneration","enrollment":18},{"nctId":"NCT02824601","phase":"PHASE2","title":"Photodynamic Therapy in Endodontic Treatment","status":"COMPLETED","sponsor":"Universidade Estadual Paulista Júlio de Mesquita Filho","startDate":"2015-02","conditions":"Endodontic Disease","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Calcium hydroxide intracanal medication application","genericName":"Calcium hydroxide intracanal medication application","companyName":"Suez Canal University","companyId":"suez-canal-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium hydroxide acts as an intracanal medicament that creates an alkaline environment to disinfect the root canal system and promote healing. Used for Intracanal disinfection in endodontic therapy, Root canal treatment as an inter-appointment medicament, Management of infected root canals and periapical pathology.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}