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calcipotriene + clobetasol propionate
calcipotriene + clobetasol propionate is a Topical combination therapy (vitamin D analog + corticosteroid) Small molecule drug developed by Leon Kircik, M.D.. It is currently FDA-approved for Plaque psoriasis, Psoriatic dermatitis. Also known as: Sorilux foam + Olux E foam.
Calcipotriene is a vitamin D analog that regulates skin cell differentiation and proliferation, while clobetasol propionate is a potent corticosteroid that suppresses inflammation and immune response in the skin.
Calcipotriene is a vitamin D analog that regulates skin cell differentiation and proliferation, while clobetasol propionate is a potent corticosteroid that suppresses inflammation and immune response in the skin. Used for Plaque psoriasis, Psoriatic dermatitis.
At a glance
| Generic name | calcipotriene + clobetasol propionate |
|---|---|
| Also known as | Sorilux foam + Olux E foam |
| Sponsor | Leon Kircik, M.D. |
| Drug class | Topical combination therapy (vitamin D analog + corticosteroid) |
| Target | Vitamin D receptor (VDR) and glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Calcipotriene binds to vitamin D receptors on keratinocytes and immune cells, promoting normal differentiation and reducing hyperproliferation characteristic of psoriasis. Clobetasol propionate, a Class I (super-potent) topical corticosteroid, activates glucocorticoid receptors to rapidly reduce inflammation, itching, and erythema. The combination provides synergistic anti-inflammatory and anti-proliferative effects for enhanced efficacy in psoriatic plaques.
Approved indications
- Plaque psoriasis
- Psoriatic dermatitis
Common side effects
- Skin atrophy
- Burning or stinging at application site
- Folliculitis
- Hypercalcemia (with systemic absorption)
Key clinical trials
- A Psoriasis Plaque Test Comparing Products for the Treatment of Psoriasis Vulgaris (PHASE1)
- Improvement of Psoriasis Patients' Adherence to Topical Drugs (NA)
- Efficacy, Safety, Preference and Response Duration of Clobex® Spray and Taclonex® Ointment in Psoriasis (PHASE4)
- Evaluation of the Vasoconstriction Properties of MC2-01 Cream (PHASE1)
- Role of Topical Treatments in the Modulation of Skin Microbiome in Psoriatic Skin (PHASE2)
- Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea (PHASE1)
- 1404003_OpenPsori.PlaqueTest to Eval.Eff.of Diff.Comp. to Mapracorat (PHASE1)
- Vasoconstriction Trial With LEO 90100 Aerosol Foam (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- calcipotriene + clobetasol propionate CI brief — competitive landscape report
- calcipotriene + clobetasol propionate updates RSS · CI watch RSS
- Leon Kircik, M.D. portfolio CI
Frequently asked questions about calcipotriene + clobetasol propionate
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Who makes calcipotriene + clobetasol propionate?
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Related
- Drug class: All Topical combination therapy (vitamin D analog + corticosteroid) drugs
- Target: All drugs targeting Vitamin D receptor (VDR) and glucocorticoid receptor (GR)
- Manufacturer: Leon Kircik, M.D. — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Plaque psoriasis
- Indication: Drugs for Psoriatic dermatitis
- Also known as: Sorilux foam + Olux E foam
- Compare: calcipotriene + clobetasol propionate vs similar drugs
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