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Bus and Dex
Bus and Dex is a combination of busulfan and dexamethasone used to condition patients prior to hematopoietic stem cell transplantation.
Bus and Dex is a combination of busulfan and dexamethasone used to condition patients prior to hematopoietic stem cell transplantation. Used for Conditioning regimen for hematopoietic stem cell transplantation in hematologic malignancies and bone marrow disorders.
At a glance
| Generic name | Bus and Dex |
|---|---|
| Sponsor | The Cleveland Clinic |
| Drug class | Alkylating agent + corticosteroid combination |
| Modality | Small molecule |
| Therapeutic area | Oncology / Hematology |
| Phase | FDA-approved |
Mechanism of action
Busulfan is an alkylating agent that causes myeloablation by cross-linking DNA, while dexamethasone is a corticosteroid that provides immunosuppression and reduces inflammation. Together, they prepare the bone marrow for donor stem cell engraftment by eliminating host hematopoietic and immune cells.
Approved indications
- Conditioning regimen for hematopoietic stem cell transplantation in hematologic malignancies and bone marrow disorders
Common side effects
- Myelosuppression
- Mucositis
- Nausea and vomiting
- Hepatotoxicity
- Infection
- Hyperglycemia
Key clinical trials
- Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies (EARLY_PHASE1)
- Palonosetron, Ondansetron, and Dexamethasone for Delayed Nausea and Vomiting in Autologous Transplant Patients (PHASE2)
- Dexmed/Buspirone Synergism on Shivering (PHASE4)
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bus and Dex CI brief — competitive landscape report
- Bus and Dex updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI