{"id":"bus-and-dex","safety":{"commonSideEffects":[{"rate":null,"effect":"Myelosuppression"},{"rate":null,"effect":"Mucositis"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL433586","moleculeType":"Small molecule","molecularWeight":"378.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Busulfan is an alkylating agent that causes myeloablation by cross-linking DNA, while dexamethasone is a corticosteroid that provides immunosuppression and reduces inflammation. Together, they prepare the bone marrow for donor stem cell engraftment by eliminating host hematopoietic and immune cells.","oneSentence":"Bus and Dex is a combination of busulfan and dexamethasone used to condition patients prior to hematopoietic stem cell transplantation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:25.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Conditioning regimen for hematopoietic stem cell transplantation in hematologic malignancies and bone marrow disorders"}]},"trialDetails":[{"nctId":"NCT04776850","phase":"EARLY_PHASE1","title":"Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies","status":"WITHDRAWN","sponsor":"M.D. Anderson Cancer Center","startDate":"2020-12-29","conditions":"Beta Thalassemia Major, Sickle Beta 0 Thalassemia, Sickle Beta Plus Thalassemia","enrollment":""},{"nctId":"NCT01370408","phase":"PHASE2","title":"Palonosetron, Ondansetron, and Dexamethasone for Delayed Nausea and Vomiting in Autologous Transplant Patients","status":"COMPLETED","sponsor":"Northside Hospital, Inc.","startDate":"2012-02","conditions":"Chemotherapy-induced Nausea and Vomiting","enrollment":85},{"nctId":"NCT00334360","phase":"PHASE4","title":"Dexmed/Buspirone Synergism on Shivering","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2004-09","conditions":"Hypothermia","enrollment":8},{"nctId":"NCT00002798","phase":"PHASE3","title":"Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"1996-08","conditions":"Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7), Childhood Acute Monoblastic Leukemia (M5a)","enrollment":880}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Bus and Dex","genericName":"Bus and Dex","companyName":"The Cleveland Clinic","companyId":"the-cleveland-clinic","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bus and Dex is a combination of busulfan and dexamethasone used to condition patients prior to hematopoietic stem cell transplantation. Used for Conditioning regimen for hematopoietic stem cell transplantation in hematologic malignancies and bone marrow disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}