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Bupivacaine + Sufentanil epidural
Bupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu receptors to provide analgesia, together delivering epidural anesthesia and pain relief.
Bupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu receptors to provide analgesia, together delivering epidural anesthesia and pain relief. Used for Epidural anesthesia and analgesia for surgical procedures, Epidural pain management in labor and delivery.
At a glance
| Generic name | Bupivacaine + Sufentanil epidural |
|---|---|
| Also known as | Epidural analgesia with bupivacaine and sufentanil |
| Sponsor | Charles University, Czech Republic |
| Drug class | Local anesthetic + opioid combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu opioid receptor (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade in the epidural space. Sufentanil is a potent synthetic opioid that activates mu opioid receptors in the central and peripheral nervous system, enhancing analgesia. The combination provides synergistic anesthetic and analgesic effects when administered epidurally.
Approved indications
- Epidural anesthesia and analgesia for surgical procedures
- Epidural pain management in labor and delivery
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Pruritus
- Urinary retention
- Respiratory depression
Key clinical trials
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
- Norepinephrine in Caesarian Section (PHASE4)
- Regional Anesthesia Techniques in Breast Surgery (NA)
- PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous (NA)
- The Effects of Combined Spinal Epidurals on Fever During Labor of First-Time Mothers (NA)
- PIEB vs CEI for Labor Analgesia: An MLAC Study (PHASE4)
- Spinal Prilocaine for Caesarian Sections (NA)
- The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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