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Bupivacaine Spinal 0,5% Heavy - titration
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Spinal anesthesia for surgical procedures, Spinal anesthesia for obstetric procedures.
At a glance
| Generic name | Bupivacaine Spinal 0,5% Heavy - titration |
|---|---|
| Also known as | Rose titration |
| Sponsor | Centre of Postgraduate Medical Education |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels (Nav) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and conduction of nerve impulses. The 0.5% heavy formulation (isobaric or hyperbaric) is used for spinal anesthesia, where it diffuses into the cerebrospinal fluid to block sensory and motor nerves in a dose-dependent manner. Titration allows gradual dosing to achieve the desired level of anesthesia while minimizing systemic toxicity.
Approved indications
- Spinal anesthesia for surgical procedures
- Spinal anesthesia for obstetric procedures
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Nausea
- Transient neurological symptoms
- Urinary retention
- Bupivacaine toxicity (systemic)
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