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Bupivacaine SNB
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Postoperative pain management via nerve block.
At a glance
| Generic name | Bupivacaine SNB |
|---|---|
| Also known as | Bupivacaine |
| Sponsor | Pacira Pharmaceuticals, Inc |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. SNB (Selective Nerve Block) formulations are designed for prolonged regional anesthesia with improved safety profiles.
Approved indications
- Local anesthesia for infiltration, nerve block, and regional anesthesia procedures
- Postoperative pain management via nerve block
Common side effects
- Injection site reactions
- Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
Key clinical trials
- Shoulder Anterior Capsular Block for Postoperative Analgesia in Arthroscopic Rotator Cuff Repair Surgery (NA)
- Postoperative Quality of Recovery After Combined Lumbar Plexus-Sciatic Nerve Block (LPB-SNB) (PHASE3)
- Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty (PHASE4)
- Analgesic Efficacy of Saphenous Nerve Block in Total Knee Replacement (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine SNB CI brief — competitive landscape report
- Bupivacaine SNB updates RSS · CI watch RSS
- Pacira Pharmaceuticals, Inc portfolio CI