{"id":"bupivacaine-snb","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmias)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. SNB (Selective Nerve Block) formulations are designed for prolonged regional anesthesia with improved safety profiles.","oneSentence":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:16:46.834Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve block, and regional anesthesia procedures"},{"name":"Postoperative pain management via nerve block"}]},"trialDetails":[{"nctId":"NCT06969625","phase":"NA","title":"Shoulder Anterior Capsular Block for Postoperative Analgesia in Arthroscopic Rotator Cuff Repair Surgery","status":"RECRUITING","sponsor":"Zagazig University","startDate":"2025-06-01","conditions":"Arthroscopic Rotator Cuff Repair","enrollment":60},{"nctId":"NCT06301503","phase":"PHASE3","title":"Postoperative Quality of Recovery After Combined Lumbar Plexus-Sciatic Nerve Block (LPB-SNB)","status":"COMPLETED","sponsor":"Udayana University","startDate":"2024-03-09","conditions":"Lower Extremity Surgery","enrollment":100},{"nctId":"NCT02284386","phase":"PHASE4","title":"Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2014-12","conditions":"Pain","enrollment":15},{"nctId":"NCT01991288","phase":"PHASE4","title":"Analgesic Efficacy of Saphenous Nerve Block in Total Knee Replacement","status":"COMPLETED","sponsor":"Cork University Hospital","startDate":"2012-11","conditions":"Post Operative Pain","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bupivacaine"],"phase":"marketed","status":"active","brandName":"Bupivacaine SNB","genericName":"Bupivacaine SNB","companyName":"Pacira Pharmaceuticals, Inc","companyId":"pacira-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures, Postoperative pain management via nerve block.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}