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Bupivacaine Injection
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia, Pain management in surgical and dental procedures.
At a glance
| Generic name | Bupivacaine Injection |
|---|---|
| Also known as | evaluation of pain by using two different types of local anesthesia, Marcaine, Bupivacaine Hydrochloride Injection, stellate ganglion block, Bupivacaine HCl (Marcaine 0.25% with epinephrine 1:200,000) |
| Sponsor | Ciusss de L'Est de l'Île de Montréal |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve fibers, stabilizing the neuronal membrane and raising the threshold for electrical excitability. This action prevents depolarization and propagation of action potentials, resulting in loss of sensation in the injected area. It has a longer duration of action compared to other local anesthetics due to its high lipophilicity and protein binding.
Approved indications
- Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia
- Pain management in surgical and dental procedures
Common side effects
- Nervousness or anxiety
- Dizziness or lightheadedness
- Tinnitus
- Tremor
- Hypotension
- Bradycardia
- Allergic reactions (rare with amides)
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery (NA)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine Injection CI brief — competitive landscape report
- Bupivacaine Injection updates RSS · CI watch RSS
- Ciusss de L'Est de l'Île de Montréal portfolio CI