Last reviewed · How we verify
Bupivacaine Hydrochloride combined with dexamethasone
Bupivacaine Hydrochloride combined with dexamethasone is a Local anesthetic with corticosteroid adjuvant Small molecule drug developed by Zhejiang Cancer Hospital. It is currently FDA-approved for Local and regional anesthesia for surgical procedures, Post-operative pain management. Also known as: SB Group (control group).
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and edema at the injection site.
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and edema at the injection site. Used for Local and regional anesthesia for surgical procedures, Post-operative pain management.
At a glance
| Generic name | Bupivacaine Hydrochloride combined with dexamethasone |
|---|---|
| Also known as | SB Group (control group) |
| Sponsor | Zhejiang Cancer Hospital |
| Drug class | Local anesthetic with corticosteroid adjuvant |
| Target | Voltage-gated sodium channels (bupivacaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx through nerve cell membranes, preventing depolarization and blocking pain signal transmission. Dexamethasone, a corticosteroid, is combined to reduce post-operative inflammation, swelling, and pain duration by suppressing inflammatory mediators. This combination extends anesthetic duration and improves post-operative analgesia.
Approved indications
- Local and regional anesthesia for surgical procedures
- Post-operative pain management
Common side effects
- Injection site reactions (pain, swelling)
- Transient nerve irritation
- Systemic toxicity from bupivacaine (rare)
- Hyperglycemia (from dexamethasone)
Key clinical trials
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block (NA)
- Interscalene vs Phrenic-sparing Blocks in Obesity and Effect of Maximum Inspiratory Pressure (NA)
- Analgesic Effects of Combined Nalbuphine-bupivacaine Versus Dexamethasone-bupivacaine in Pericapsular Nerve Group Block (PENG) After Hip Surgeries: A Randomized Clinical Study (NA)
- Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section (NA)
- Interscalene Block Versus Combined Infraclavicular-Anterior Suprascapular Blocks for Shoulder Surgery (NA)
- Evaluation of the Effectiveness of Pericapsular Nerve Group Block in Hemiplegic Shoulder Pain
- Dexamethasone and Bupivacaine for Pain After Hernia Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine Hydrochloride combined with dexamethasone CI brief — competitive landscape report
- Bupivacaine Hydrochloride combined with dexamethasone updates RSS · CI watch RSS
- Zhejiang Cancer Hospital portfolio CI
Frequently asked questions about Bupivacaine Hydrochloride combined with dexamethasone
What is Bupivacaine Hydrochloride combined with dexamethasone?
How does Bupivacaine Hydrochloride combined with dexamethasone work?
What is Bupivacaine Hydrochloride combined with dexamethasone used for?
Who makes Bupivacaine Hydrochloride combined with dexamethasone?
Is Bupivacaine Hydrochloride combined with dexamethasone also known as anything else?
What drug class is Bupivacaine Hydrochloride combined with dexamethasone in?
What development phase is Bupivacaine Hydrochloride combined with dexamethasone in?
What are the side effects of Bupivacaine Hydrochloride combined with dexamethasone?
What does Bupivacaine Hydrochloride combined with dexamethasone target?
Related
- Drug class: All Local anesthetic with corticosteroid adjuvant drugs
- Target: All drugs targeting Voltage-gated sodium channels (bupivacaine); glucocorticoid receptor (dexamethasone)
- Manufacturer: Zhejiang Cancer Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Local and regional anesthesia for surgical procedures
- Indication: Drugs for Post-operative pain management
- Also known as: SB Group (control group)
- Compare: Bupivacaine Hydrochloride combined with dexamethasone vs similar drugs
- Pricing: Bupivacaine Hydrochloride combined with dexamethasone cost, discount & access